“I envision this configurator as something we will use here at Sorama to configure our products for different settings, for example smart stadiums, busy streets and probably more.” Devansh’s prior educational experiences include a BSc in Computer Science & Engineering from Punjab Engineering College, Chandigarh, India, and a MSc in Sound and Music Computing from Aalborg University Copenhagen, Denmark. He has also worked in various IT roles with firms like JPMorgan Chase, Shell and Bosch.

“I’m glad to be a part of this exciting setup here in Eindhoven,

and I look forward to meeting you soon!”

Devansh Kandpal I EngD trainee VIPNOM project

In 2019, I started my PhD, after which we initiated a clinical study called Neurotrend in collaboration with Philips and the epilepsy centre Kempenhaeghe. Neurotrend is one of the first Eindhoven Engine OpenCall projects.

Predicting the clinical outcome

This study is aimed at predicting the clinical outcome (i.e., the course/development of a disease) of people with depression based on MRI scans. More specifically, we obtain structural, functional (activity) and vascular MRI scans of the brain of subjects with and without depression at the beginning of the study and after a year. During the one-year period, we monitor their depression symptoms and cognitive ability. In this way, we can predict how the depression will develop over time based on the first scans but also evaluate brain changes over a year and correlate this to symptom changes. The clinical study was ethically approved in 2021 and its data acquisition is almost finished at the time of writing.

Preliminary results

From the preliminary results, we can conclude that brain activity patterns and interaction between brain networks is time-varying and that including this neurodynamic nature in a model improves the prediction of depression symptom severity changes over time compared to more standard/static approaches (brain activity/synchronicity over the whole functional MRI scan). Moreover, we demonstrate that a relatively novel MRI acquisition method, called multi-echo multiband imaging, increases the functional MRI signal quality and improves, amongst other things, the temporal resolution. This is beneficial as it allows us to more reliably model network interactions. Another interesting finding was the fact that brain volume and tissue properties of several limbic structures, which are known to be involved in emotion processing, also have predictive value for clinical outcome in depression. A smaller amygdala (associated with fear processing) volume correlated significantly with a higher number of lifetime depressive episodes.

Improving the models and interpreting clinical meaning

In the last period of the PhD, I will focus on improving the models and interpreting the clinical meaning of these results, which will further help in understanding the aberrant brain mechanisms in subjects with depression. We hope to show other researchers the direction in which we think future MRI studies related to psychiatric disorders should head. Taking into account the complex, dynamically interactive brain while implementing the aforementioned MRI acquisitions could lead to more replicative results, especially if carried out in studies with a larger sample size. Even though we will not yet be able to apply these models in the clinic to support (still subjective) clinical decision-making, we are contributing significantly to existing depression-related MRI research. We have demonstrated the potential of state-of-the-art analyses and acquisitions in combination with a multi-modal MRI-based longitudinal study for depression diagnosis/prognosis purposes.

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The experience of creating a mobile game that had such success in my home country of Brazil made me think that maybe this could be the right path for me: finding a way to put together my skills and my desire to change people’s lives through design. That was one of the reasons that led me to apply for an EngD position at TU/e to work in the Emergence Lab at Eindhoven Engine on Low Literacy and the Future of Work projects.

Focus within low literacy

Nowadays, almost 2.5 million people are low literate just in the Netherlands and this number is increasing over time. It is known that there are different types of literacy, but we are focusing on reading and writing abilities since these are the main forms of communication and access to knowledge in contemporary society. On top of that, there is a shortage of teachers for all these people, so we should use technology such as Artificial Intelligence, digital games and social media to tackle this problem. However, low literacy, as you might imagine, is a complex problem. Choosing a traditional way of designing is not the right decision.

Using design thinking

Up to this moment, I have been studying in order to better understand this issue, following design thinking steps as an approach. At the same time, I am learning how to develop a way of thinking that is systemic and takes into account the complexity of this wicked problem. I am being supported by an excellent team of teachers and I believe that the EngD program is helping me to have access to the latest research in AI interaction and user experience, guiding me to become a more human and complete designer. Regarding the language (you might be asking yourself), since I don’t speak Dutch (yet), I am following interviews by Dutch students with the target group to get information on how we can develop a solution that really will help them.

Finally, my next steps will be developing a prototype to be tested with the target group until the end of the year and then making the necessary changes to adapt to their needs. Also, I wish to extend this project to my home country and – why not? – more countries.

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Let’s disrupt 2023 lunch

“It is so nice to get acquainted with the Eindhoven Engine projects, which are very diverse in terms of technical subjects,” says Janne. “Being engineers, we like this! In other respects, the projects are very similar: the energy and inventiveness are high. And also the involvement with each other, as shown, for instance, in the 5-weeklys.”

What also became clear in the past two months is that it is getting busier and more dynamic at our beautiful location in Disruptor. It is often a puzzle to find a workplace or workshop space for everyone with the increasing number of activities of projects and student groups. How different this was only half a year ago. It means a lot to us as the Eindhoven Engine core team: now that the COVID time is definitely behind us, we see the fruits of our efforts to turn our offices into a vibrant innovation location.

We are also making plans for the future: Maarten (Steinbuch, scientific director at Eindhoven Engine) and Janne are busy working out two scenarios for the future of Eindhoven Engine, aligning with the Brainport agenda and in close consultation with our critical friends. More on this later in the year. Stay tuned!

Events in January and February 2023

“In my current role as director at Bureau WO, I deal with the strategy regarding changes within ecosystems,” Janne explains. “Innovations can enter the market faster by including the larger context as a degree of freedom for change. With this approach, I hope to contribute to the success of Eindhoven Engine. I look forward to working with the energetic team in order to take Eindhoven Engine to the next level.”

“Innovations can enter the market faster by including the larger context as a degree of freedom for change.”

Janne Brok | Managing Director Eindhoven Engine

 

Janne joins Eindhoven Engine at an excellent time. Following the successful OpenCalls and the current portfolio of innovation projects, she will work with Maarten Steinbuch and the team to further build on this success and shape the next phase.

Janne has been assigned to Eindhoven Engine for three days a week. In addition, she will continue to carry out her duties as director of Bureau WO.

Following the submission deadline of 4 June, a team of experts has examined the 11 projects submitted. Each of the projects was first assessed against formal criteria which had been published in advance and which set a high quality standard. Paul Merkus, coordinator of the OpenCall: “The text of the OpenCall 2020 was clear, which allowed the evaluation process to run smoothly and fairly. The team of experienced, independent experts was able to determine the ranking of the nine eligible proposals on the basis of these criteria. I’m proud of that.” Yesterday, the Advisory Board of Eindhoven Engine – with representatives from the knowledge institutions TU/e, TNO and Fontys and the business community – also gave a positive recommendation on the proposed selection of projects.

“In this time of the corona pandemic in particular, we see a great need for innovation. Companies and knowledge institutions have worked together intensively to come up with strong project proposals,” add directors Katja Pahnke and Maarten Steinbuch. “We therefore see a nice mix of diversity in the consortia. Eindhoven Engine is picking up more and more steam.” The projects are highly diverse in their focus: climate, vitality, health and smart manufacturing.
“Co-creation and co-location are the basic ingredients for unlocking collective intelligence in order to give a boost to innovation: this is Eindhoven Engine’s way of working. We look forward to the participating consortia soon becoming part of our ecosystem.”

Eindhoven Engine

Eindhoven Engine unlocks the collective intelligence in the Brainport region. Thanks to a unique formula, innovators from companies can join forces with students and experienced employees from knowledge institutions in order to work together to accelerate innovation and realize disruptive co-creation projects in which co-location is a prerequisite. The founding fathers of Eindhoven Engine are the knowledge institutions Fontys, TNO and Eindhoven University of Technology and the companies Philips Healthcare, Signify, ASML, VDL, NTS and NXP. Eindhoven Engine’s funds come from the Brainport Region Deal.

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Background information on projects

For each of the projects, co-location at Eindhoven Engine is an attractive form of added value. Through this, Eindhoven Engine increases the chances of inspiring encounters. The Eindhoven Engine academy complements this with coaching and pioneering insights.

Carbyon

Humanity is facing an unprecedented challenge: global warming, driven by carbon dioxide (CO₂) emissions from fossil sources such as oil and gas. However, these emissions, if captured, can be a renewable carbon source with applications such as crop growth and sustainable fuel synthesis. Carbyon will develop Direct Air Capture (DAC) technology to remove CO₂ from the atmosphere and turn it into a green substitute to fossil fuels. As the global demand for renewable carbon will increase once the price level reaches €50 per ton of CO₂, Carbyon is challenging multidisciplinary teams within Eindhoven Engine to collaboratively improve the main cost drivers of DAC technology.

Partners: Carbyon, DIFFER, TU/e

SmartMan

Smart Manufacturing (SmM) aims to improve factory efficiency by optimizing production processes, but SMEs often lack the capacity to create innovation in this domain. Bringing together Eindhoven Engine, Fontys, TNO and Brainport Industries Campus, the SmartMan project comprises research into various facets of SmM, including robot-assisted manufacturing, data sharing, industrial AI, virtual reality and autonomous transport. Student projects will be executed at SMEs with the goal of developing knowledge, technology and methods for combining quality, automation and flexibility in manufacturing. Success will be measured in terms of the economic value of improvements per project and company.

Partners: Fontys, TNO, Smart Industry Fieldlab Flexible Manufacturing partners, VDL, VBTI and several SMEs

ECoS-IAQ

Efficient Comfortable School Indoor Air Quality

Installations in buildings are responsible for around 35% of all energy consumption, approximately 20% of which is due to inefficient operations. Inferior environmental conditions within classrooms can have both short- and long-term health effects, mainly due to the presence of particulate matter. With greater insights into sensors, data interpretation, trend signaling, continuous monitoring, fault detection/diagnosis and predictive maintenance, problems can be identified in the Heating Ventilation Air Conditioning (HVAC) systems of schools. The ECoS-IAQ project focuses on the creation of product development concepts for air handling manufacturers, air filter manufacturers, control companies and installers.

Partners: Building G100, Camfil, ISSO, Kropman, Lucas Onderwijs, NedAir, TU/e

iHeat@Home

The iHeat@Home project contributes to a breakthrough innovation in thermal energy storage: a heat battery which is better, cheaper, smaller and greener than any competitor. This will accelerate the energy transition, promote the development of renewable energy sources, reduce grid investments and create new business. This is all happening here in the Brainport region. iHeat@Home focuses on solutions for real-time data on the heat battery’s state-of-charge and its optimal data management, with three coherent solutions: 1. The basis for a sensor which is robust and cheap; 2. Communication protocols and data management; 3. Integration in a validated, user-ready heat battery. The aim is to bring this technology to the market by 2023.

Partners: Caldic, Fontys, TNO, TU/e, Warmtebatterij BV

POWErFITTing

FITTing Persons’ vitality and optimizing their Work Environment

In an increasingly competitive global economy, physical inactivity and burnout rates are increasing. Sustainable employability based on good physical and mental health is therefore crucial, preventing absenteeism and also reducing healthcare costs. POWer FITTing optimizes the relationship between vitality and the (home) office environment through the combination of data acquisition, integration and application for the validation and acceleration of user-oriented solutions. By taking into account individual, societal and contextual factors, this enables employees to remain both healthy and productive. This benefits companies, individuals and wider society.

Partners: Fontys, HC Oranje-Rood, IMEC, TNO, TU/e

Wombath: towards an artificial womb

Following their birth, each child faces a physiological transition from mother-placental life support to (self-sufficient) life outside the womb. For some premature babies, this transition occurs too quickly. This places a heavy demand on the child’s immature vital organs, which is why extremely premature babies often experience serious, lifelong health problems with possible social consequences. As a trial in recent years, premature lambs have successfully been kept alive in a fluid-based environment, allowing them to develop in the same way as in the womb. The results are also promising for human application. The WOMBATH consortium will develop a medical device – an artificial womb – that supports the safe development of extremely premature babies outside of the womb. Ultimately, these infants will have better health prospects than premature infants with conventional care.

Partners: LifeTec Group, Máxima Medical Center, MEDSIM, NEMO Healthcare, POLIMI, RWTH Aachen, TU/e